Biocell Guide

Biocell Guide | Biocell Liquid Collagen


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Biocell Collagen

About Liquid Biocell

Liquid BioCell is a new generation of collagen that utilizes cell technology to maximize absorption of collagen in the human body and to optimize skin health and collagen synthesis.

Liquid  Biocell HA Matrix Technology aims to nourish and support the skin and joints as well as improving skin hydration, reducing the appearance of crow’s feet and wrinkles, and promoting healthy bone, skin, hair, teeth and nails.

Liquid BioCell  is a GRAS  (Generally Regarded As Safe) supplement that is non-GMO, allergen free (gluten, soy, shellfish, fish, egg, milk, peanuts, and sugar) and has been scientifically studied for safety, effectiveness, and bioavailability.

Biocell Collagen HA Matrix

HA Matrix

What is Biocell HA Matrix?

BioCell HA Matrix is a clinically studied dietary supplement that is made of naturally occurring hydrolyzed type II collagen peptides, chondroitin sulfate, and hyaluronic acid that mimics the structure of collagen in the human body.  By replicating actual collagen structure assists the body in absorbing synthetic collagen supplement.

Biocell Research

Biocell Technology

Collagen Bioengineering

Collagen HA Matrix

Research Data

Collagen BioEngineering

Numerous advancements in the field of collagen-based biomaterials have occurred over the last decade. Production and cross-linking processes have progressed and improved, from injectable collagen matrices to bone regeneration scaffolds.


Collagen is currently frequently used in research as well as medical applications. 


Because collagen is found in every connective tissue, it is one of the most studied extracellular matrix macromolecules (ECM). This fibrous protein type is the main component of skin and bone, accounting for around 25% of mammals’ total dry weight [1]. To date, 29 different collagen types have been identified, all of which contain a characteristic triple helix shape. Collagen fibers are known to be formed by collagen types I, II, III, V, and XI. Because of their chemical structure, collagen molecules are made up of three chains that combine together. Each chain is made up of about a thousand amino acids. 

Benefits of Biocell Collagen

Restores Youthful Skin

  • * Reduce fine lines, wrinkles, and crow’s feet on the face
  • * Reduce facial skin dryness and scaling
  • * Prevent Skin Aging
  • * Improve skin elasticity
  • * Increase collagen and hyaluronic acid levels *

Strengthens Hair, Skin and Nails

  • * Encourages healthy hair, skin and nails.
  • * Clinically shown to promote collagen & keratin health.
  • * Supports skin suppleness & elasticity
  • * Increase the strength of nails to reduce brittleness

Improves Joint and Cartilage

  •  * Enhance joint comfort and mobility
  • * Relieve joint pain
  • * Strengthen joints and cartilage
  • * Promote post-exercise recovery

Athletic Improvements

  • * Boost Muscle Mass
  • * Reduce Bone Loss
  • * Promote Heart Health


What is Biocell Collagen?

BioCell Collagen is a clinically researched dietary supplement made of hydrolyzed collagen type II peptides, chondroitin sulfate, and hyaluronic acid. BioCell Collagen is a bioengineered matrix scaffold structure that mimics the structure of collagen in the human body which improves absorption and bioavailability.


  • * BioCell Collagen promotes healthy connective tissues, joints, skin, hair, teeth and nails as well as restoring the appearance of youthful skin.
  • * BioCell Collagen® is a clinically researched branded ingredient that has been studied for clinical efficacy as well as being affirmed as GRAS (Generally Regarded As Safe). 
  • * BioCell Collagen is non-GMO and free of gluten, soy, shellfish, fish, egg, milk, peanuts and sugar. 

What are the active ingredients in Liquid Biocell?

BioCell Collagen is a dietary supplement derived from hydrolyzed chicken sternal cartilage extract that includes 60% Hydrolyzed Collagen Type II (as Total Protein), 20% Chondroitin Sulfate, and 10% Hyaluronic Acid. 


Collagen is the prevalent protein in joint cartilage and the dermis of the skin. It provides the structural framework for the bodies connective tissues and skin. 


Chondroitin sulfate is a naturally occurring component of joint cartilage that gives joints its shock-absorbing abilities.


Hyaluronic acid (HA) is a substance that contributes to skin hydration, joint lubrication, and cell adhesion.


Note: Gluten-free, soy-free, shellfish-free, fish-free, egg-free, milk-free, peanut-free, and sugar-free.

What is the difference between Biocell Collagen and Collagen Peptides?

Biocell Collagen differs from other Collagen ingredients as it is a matrix structure and not a mixture of separate ingredients.  The HA matrix is composed of biomolecules that mimic the scaffolding structure of collagen in the human body.


Also Biocell Collagen has been reviewed as non-allergenic, non-irritating and non-cytoxic.  As well as being GRAS (Generally Regarded As Safe) and is non-GMO, gluten free and contains none of the following allergens : soy, shellfish, fish, egg, milk, peanuts and sugar.


  • * Non-Irritating
  • * Allergy Tested
  • * Non-Cytotoxic


The other difference between Biocell Collagen and other collagen supplements is that Biocell Collagen has been scientifically studied in over 7 clinical trials.  


For more information Biocell Collagen Clinical Trials, visit :

What are the benefits of Biocell Collagen?

  • * Reduces facial fine lines, wrinkles, and crow’s feet
  • * Decreases facial skin dryness and scaling
  • * Prevents Skin Aging
  • * Increase collagen and hyaluronic acid levels
  • * Strengthens Hair, Skin, and Nails
  • * Promotes healthy hair, skin, and nails
  • * Enhances skin elasticity
  • * Clinically demonstrated to support collagen and keratin health.
  • * Supports skin suppleness and elasticity
  • * Strengthens nails to minimize fragility
  • * Enhances Cartilage and Joints
  • * Enhance joint comfort and mobility
  • * Alleviate joint discomfort
  • * Strengthen cartilage and joints
  • * Enhance post-exercise recuperation
  • * Increase Muscle Mass
  • * Decrease Bone Loss
  • * Encourage Heart Health

What are the side effects of Biocell Collagen?

Following multiple published research on the efficacy of BioCell Collagen, these results demonstrate that the dietary supplement is a safe and effective and is one of the only Collagen supplements that is non-GMO and free of gluten, soy, shellfish, fish, egg, milk, peanuts and sugar.


One study over 14 weeks, showed no adverse effects and Biocell Collagen was well-tolerated by testing participants.  

What is Biocell Collagen made from?

The marketed dietary ingredient BioCell Collagen® is a hydrolyzed chicken sternal cartilage extract consisting largely of collagen type II peptides, chondroitin sulfate, and hyaluronic acid.   BioCell Collagen is manufactured from pure, hormone- and antibiotic-free dietary chicken sternal cartilage. The composition of chicken sternal cartilage closely resembles that of human cartilage, which is abundant in type II collagen, chondroitin sulfate, and hyaluronic acid.


Cartilage is a desired and clean supply since it lacks blood arteries, lymphatics, and nerves, which are known to convey infections and contaminants. Consequently, extracting just from cartilage avoids the possibility of contamination. Using a unique production method, we put the chicken sternal cartilage through filtration, purification, concentration, hydrolysis, and sterilizing to ensure quality and safety.

What is HA Matrix made of?

Collagen/HA Matrix Technology surpasses conventional collagen supplements with a unique, single-source matrix of highly absorbable type II collagen peptides, hyaluronic acid, and chondroitin sulfate.  The Collagen/HA Matrix Technology is designed to maximize absorption of Collagen in the human body.


Collagen/HA Matrix Technology is a clinically researched element in dietary supplements. It is composed of hydrolyzed collagen type II peptides, chondroitin sulfate, and hyaluronic acid that exist naturally. The BioCell matrix is not composed of distinct components but is a matrix structure which improves absorption and bioavailability.


  •  *  Collagen is the most abundant protein in joint cartilage and skin dermis. It supplies the structural underpinning of your connective tissues to maintain the firmness and elasticity of your skin and the mobility and fluidity of your joints.


  • * Hyaluronic acid (HA) is a chemical that hydrates the skin, lubricates the joints, and is the gel-like material that binds your cells together.


  • * Chondroitin sulfate is a naturally occurring component of joint cartilage that provides it with exceptional shock-absorption characteristics. This is the only nutraceutical with a patent on the market whose composition resembles that of joint cartilage.

Is it possible to take too much Collagen?

Because the Institute of Medicine has not defined a Tolerable Upper Intake Level (UL) for collagen, it is impossible to estimate how much collagen you may take before experiencing any possibly adverse consequences.

Oral collagen doses ranging from 2.5 grams to 10 grams per day for up to 24 weeks were shown to be generally safe with minimal adverse effects, according to a January 2019 review in the ​Journal of Drugs and Dermatology​.

Is Biocell Collagen Safe?

Yes, BioCell Collagen has been safely and successfully used by millions of consumers since its introduction in the market in 1998. It was affirmed GRAS (Generally Recognized as Safe) by an independent experts safety panel following rigorous scientific reviews not only in safety and toxicology data, but on manufacturing processes according to food Good Manufacturing Practices (GMP). Various research studies, including seven human clinical trials, support the safety, efficacy, and bioavailability of BioCell Collagen.


BioCell Collagen® CG is dermatologist-reviewed, and studies reveal that it is non-irritating, non-allergenic, and non-cytotoxic to human skin and cells. BioCell Collagen® CG is not tested on animals.


Dermatologist Reviewed:
* Non-Irritating
* Allergy Tested
* Non-Cytotoxic


BioCell Collagen has been granted GRAS status (Generally Regarded As Safe). BioCell Collagen does not contain any of the common allergens including wheat, soy, shellfish, fish, egg, milk, peanuts, or sugar. peanuts and sugar. 


Does BioCell Collagen provide collagens types I, II & III?

Collagen is the most abundant protein in the human body. A variety of collagen types have been discovered, with type I/III and type II being the most common in the skin dermis and articular cartilage, respectively. The hydrolyzed collagen type II in BioCell Collagen encouraged the manufacture of collagen type II from chondrocytes, and daily consumption of BioCell Collagen enhanced the collagen content in the facial skin. This implies that BioCell Collagen can boost all three forms of collagen (I, II, and III) found in joints, skin, and other connective tissues.

BioAvailability of Biocell Collagen vs Normal Collagen

In a single-dose 36-hour peak absorption trial, BioCell Collagen HA considerably rose in the blood in four hours and peaked at 7008.62% above control in twelve hours (P < 0.05). HA was rapidly degraded in the blood to two metabolites 1/600th its size.


In a 28-day steady state bioavailability study using a constant daily dose, BioCell Collagen HA and its metabolites in the blood became stable after seven days and remained significantly increased (p < 0.001) throughout the study (HA at 3542.58% above control and HA metabolite at 11890.15% above control).


“This unprecedented study on hyaluronic acid, a key element in the unique matrix of BioCell Collagen II® which consists of Collagen Type II, Chondroitin Sulfate, and Hyaluronic Acid, demonstrates a synergistic effect that allows for the impressive absorption as indicated in these exciting and promising studies. BioCell Technology has expanded its intellectual property profile and has a patent pending to cover oral and topical applications of hyaluronic acid derived from various natural sources for use in dietary supplements and cosmetics,” said Suhail Ishaq, Vice President of BioCell Technology, LLC.

Biocell Guide