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BioCell Collagen : A Closer Look at the Science Behind BioCell Collagen

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The truth about the anti-aging supplement that’s causing such a stir – Liquid BioCell Collagen the age reversing wellness supplement. 

Is there a genuine distinction between the countless collagen products available on the market?

With so much conflicting information coming from supplement companies, social media, and high-profile personalities, determining what to believe is becoming increasingly difficult.

Continue reading to discover the surprising, science-backed truth that even the majority of industry experts are unaware of.


Collagen is a protein that gives cells their structure. It is found in nearly every part of the human body, but is particularly abundant in healthy skin, joints, and connective tissue.  In your twenties, your body begins to produce less collagen.  Indeed, you lose about 1% of your collagen each year, which means that by age 50, you have nearly 30% less collagen than you did at age 20, and nearly 50% less collagen by age 70.

Collagen deficiency is the most significant internal factor contributing to visible signs of aging.  Once the intracellular matrix begins to degrade, it loses its rigidity and structural support, resulting in sagging skin and wrinkles, joint discomfort, tendon and ligament strain, and adverse effects on the eyes, nails, hair, gums, and even digestive health.

Liquid biocell before after


Dryness, wrinkles and fine lines.
Aging skin occurs to the best of us, and we’ve all experienced days when our reflection in the mirror is less vibrant than it once was.  That is why there are so many creams and lotions on the market, all vying for your attention— but how many of them actually work?

Numerous high-priced skin care products make lofty claims about restoring youthful skin, but few are backed by scientifically proven clinical evidence. 

Recent research has confirmed findings that Liquid BioCell Collagen significantly improves the appearance of the skin.


This award-winning supernutraceutical’s patented Collagen/HA Matrix Technology has been shown to improve skin in a variety of ways, including reduced facial lines and wrinkles, increased skin elasticity and hydration, increased collagen content in the skin, more even skin tone, and an overall more youthful appearance.  Participants’ skin looked noticeably better after just 12 weeks of using Liquid BioCell Collagen.


The extraordinary results demonstrated in this soon-to-be-published study were also not an aberration.  The clinical trial followed the gold standard of quality research by being randomized, double-blind, and placebo-controlled, with a test sample of 128 volunteers.  Additionally, it adds to a growing body of evidence demonstrating that Liquid BioCell collagen is an ideal way to promote natural beauty.

NOTE: At the time of publication, vegan collagen was not commercially available.  Vegan collagen products are typically deceptively labeled as such because they contain no collagen at all but instead contain common collagen-boosting ingredients such as vitamin C to capitalize on consumer demand.


Collagen can be classified as a nutritional ingredient into several categories based on its type, source, and manufacturing processes. 

Collagen is available in a variety of forms:

  • TYPE I: Hydrolyzed — This type of collagen is commonly sold as bone broth or collagen powder. It is derived from porcine skin, bovine hide, eggshell membrane, or fish.
  • TYPE II: Collagen that has not been denatured or hydrolyzed — Primarily derived from chickens.
  • Hydrolyzed: — Frequently derived from bovine sources.
  • Vegan collagen: A pending scientific development utilizing genetically modified yeast and bacteria in an attempt to meet consumer demand.

If you’ve ever heard that ingestible collagen has no benefits, you’re partially correct.  Collagen molecules in their natural state are too large to be absorbed effectively by the body and are simply digested as proteins in the digestive system.

Hydrolysis is the process by which these large collagen molecules are broken down for increased efficacy, which is why the majority of supplements contain hydrolyzed collagen.
However, the method of hydrolysis and the type and source of collagen used can have a significant impact on the end product’s quality and effectiveness.




This multi-award-winning, single-source matrix is composed of a naturally occurring combination of highly absorbable collagen, hyaluronic acid, and chondroitin sulfate in concentrations that closely match the composition of human articular cartilage.

It has been clinically proven to provide remarkable joint benefits — as well as dramatic skin benefits.



Liquid BioCell is a proprietary type II collagen that goes beyond the hydrolyzed bovine or marine collagen found in the majority of formulas.



Since its inception as the gold standard for supplemental collagen, Liquid BioCell has inspired ground-breaking trends, such as the addition of a collagen matrix ingredient, by other brands.  Despite this, Liquid BioCell remains unique in delivering all of these clinically demonstrated benefits, as demonstrated in multiple double-blind, randomized, placebo-controlled human clinical trials for visible and palpable results.


This proprietary ingredient is derived naturally from chicken sternal cartilage and hydrolyzed using a patented Bio-OptimizedTM manufacturing process to create an ideal micromolecule.  As a result, bioavailability is naturally increased.


Bioavailability is directly related to the efficacy of a supplement, as it quantifies the efficiency with which a substance enters the circulatory system.  Consuming a nutrient is insufficient; it must be absorbed in order to provide any benefit, which means that a supplement’s bioavailability may be just as important, if not more so, than what its nutrition label claims.

In human clinical trials, hyaluronic acid levels increased by 6000% over 28 days reducing wrinkles from the inside out.*


  • Counteracts skin’s natural aging and photoaging from the inside out*
  • Improves skin’s hydration, firmness and elasticity*
  • Increases skin’s collagen content*
  • Reduces the appearance of deep wrinkles and lines*
  • Helps improve skin’s microcirculation and skin tone*
  • Reduces hyaluronidase, the enzyme that causes skin aging*
  • Promotes healthy hair, nails, gums and eyes*


  • Improves joint mobility and lubrication*
  • Reduces joint discomfort*
  • Promotes healthy cartilage and connective tissue*



In a human clinical trial, dryness and scaling skin were reduced by 76% without the use of topical moisturizer at 12 weeks.*


What’s more, Liquid BioCell is scientifically proven to reduce hyaluronidase, an enzyme that significantly contributes to skin aging.*


Liquid BioCell revealed measurable improvement in joint discomfort and physical activity after 8 weeks*.

Liquid Biocell Naturally Mirrors Human Articular Cartilage Composition
Liquid Biocell Collagen Matrix


The innovations pioneered by Liquid BioCell have set new precedents in the industry. While many companies have since followed our lead, none can match the unique combination of this single-source collagen, the Collagen/HA Matrix composition and Bio-Optimized micromolecule that makes Liquid BioCell so effective. Only Liquid BioCell offers all of the following:

  • Multiple industry awards
  • 7 U.S. and international patents
  • Clinically demonstrated benefits, backed by multiple double-blind, randomized, placebo-controlled human clinical trials
  • Naturally sourced matrix (not a blend), consisting of hydrolyzed type II collagen (60%), hyaluronic acid (10%) and chondroitin sulfate (20%)
  • Patented Collagen/HA Matrix that mirrors natural articular cartilage*
  • Patented Bio-Optimized process that results in the ideal molecular weight for enhanced absorption
  • Liquid delivery system
  • Concentrated formula, requiring only 2 tablespoons per day
  • Multi-faceted benefits extend to skin, joint and connective tissue health*


Liquid BioCell uses a highly bioavailable liquid form of a patented sternal cartilage that is a matrix of collagen, hyaluronic acid and chondroitin. It is derived from a byproduct of humanely treated chickens raised free of GMOs, antibiotics and hormones on the world’s most reputable and regulated farms located in the US and Europe. As part of our commitment to sustainability, we use chicken byproduct from parts that the farms would otherwise discard after processing the chickens for their meat.

Hyaluronic acid is a natural compound that exists throughout the body and is most commonly found in the eyes, joints and skin. Its molecular structure gives it a unique ability to retain large amounts of water, which affects the body’s moisture content and directly impacts the appearance of wrinkles, fine lines, dry skin and skin’s firmness. It is also a crucial component of synovial fluid for sufficient joint lubrication.*

Naturally found in connective tissue, chondroitin sulfate is one of the building blocks of cartilage. Its job is to help cushion joints and provide elasticity and resistance. Chondroitin sulfate supports joint, bone, ligament and tendon health for optimal mobility and can play a key role in living a more active lifestyle as you age.*

In the simplest terms, Liquid BioCell consists of type II hydrolyzed collagen, a major component of healthy joints, youthful skin and connective tissue; hyaluronic acid (HA), essential to skin hydration, tissue maintenance and a youthful appearance; and chondroitin sulfate to support joint flexibility and lubrication.*

Liquid BioCell products were developed by collagen expert Asma Ishaq. Asma has pioneered the collagen industry and continues to lead as Chair of the Board of Directors for the Collagen Stewardship Alliance, dedicated to ingredient transparency, globally sustainable collagen sourcing, ingredient quality and integrity. As Modere CEO, Asma was recognized in 2021 by Forbes as a top CEO in the health and beauty ecommerce space. Liquid BioCell is a result of research that was being done on an ingredient called hyaluronic acid or HA, which was thought to be associated with longer life spans. The medical community and researchers were very interested in the science, however found that the natural state of HA was too large for the body to absorb. Asma and her team’s interest in this science led to the discovery of a unique natural source of HA, which also coexisted with collagen and chondroitin sulfate as it does in the human body. The raw material was tested and developed into micromolecules that could actually be absorbed by the body. This nutraceutical ingredient was awarded 7 US and international patents and is called BioCell Collagen.*

Results prove that the body readily recognizes and accepts Liquid BioCell in controlled clinical environments where researchers can compare collagen and hyaluronic acid levels in the skin and in the blood of participants at weekly intervals.

The data shows measured increases in collagen and hyaluronic acid among study participants, indicating Liquid BioCell is formulated at a molecular weight that is effectively absorbed into the bloodstream and isn’t broken down in the digestive system is the same way as typical collagen proteins.

Liquid BioCell features an advanced liquid delivery system that is designed not only to be easy to use, but also tastes good. And people are more likely to take a supplement consistently if it is easy to use, which in turn improves efficacy and results.

Patents help Modere protect our ingredients, processes and innovation. All 7 Collagen/HA Matrix patents have been awarded based on the technology’s unique composition. It’s the first formula ever to feature Bio-Optimized collagen, hyaluronic acid and chondroitin sulfate in a matrix that mimics human body composition. The formula’s usage and manufacturing process are also patented.

Dietary supplements are subject to strict FDA regulations in the United States. However, whereas drugs require FDA approval prior to sale, the FDA does not approve or reject dietary supplements, including those derived from a natural source like Liquid BioCell.
In Canada, Liquid BioCell and products containing this ingredient are authorized for sale by Health Canada, the country’s regulatory equivalent of the FDA (NPN: 80108933, 80090542, 80108932, 80096623, 80097727).

More information about studies on Liquid BioCell can be found on and on individual Liquid BioCell product pages, where you’ll find our Science of Collagen brochure. Additionally, a list of scientific references can be found at the end of this document. Every benefit claim we make is substantiated with scientific research. The FDA regulates supplement claims, and as a leader in collagen supernutraceuticals for over 20 years, Modere prioritizes FDA compliance. To avoid implied claims related to medical conditions or disease, we don’t publish specific studies in our printed materials.

Our independent research is conducted via multiple double-blind, randomized, placebo-controlled human clinical trials and is third-party validated. These criteria are universally considered the highest standard for clinical studies in the scientific community.

These are pictures of what Liquid BioCell has done for real people who took the daily dose for 12 weeks†.


Although selected studies on our ingredient have been published in peer-reviewed journals, Modere opts to strictly limit the publication of studies on Liquid BioCell in scientific journals in order to protect proprietary data. However, the physicians who sit on the Modere Scientific Advisory Board have had many years of experience using Liquid BioCell successfully with their patients.

Collagen is a buzzword right now, not only among social media influencers and beauty bloggers, but in the medical community as well. Unfortunately, many so-called “experts” are inadvertently spreading misinformation about collagen supplementation. While it is true that many collagen products are more hype than help, popular media figures and even physicians who make generalizations about unproven or false claims by manufacturers are often not educated on the latest research.


Attempts to discredit collagen supplements do not take into account our clinical studies, which prove that the unique Collagen/HA Matrix in Liquid BioCell works very differently than typical hydrolyzed collagen. When shopping for a collagen supplement, look for one that is backed by clinical research. Make sure that research cited includes direct references to the specific ingredient or product you’re considering.

Liquid BioCell is not a drug; it is a nutritional supplement. There is no evidence that Liquid BioCell interferes with any medications. However, if you’re on medication, we recommend that you speak with your physician before starting any new supplement.

No studies have been done on Liquid BioCell during pregnancy. We encourage you to speak with your physician before starting a new supplement, whether or not you are pregnant.

Work Cited:

Effects of Oral Administration of Type II Collagen on …. Trentham et al. 1993, Science, pp. 261: 1727-1730.

Hyaluronic acid in cutaneous intrinsic aging. Ghersetich et al. 1994, Int J Dermatol, pp. 33(2): 119-122.

Hyaluronic acid stimulates human … within a collagen matrix. Greco et al. 1998, J Cell Physiol, pp. 177(3): 465-473.

A randomized double-blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II (BioCell Collagen II®) in adults with …. Sheldon et al. 2003, Miami Research Associates.

Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Oesser et al. 2003, Cell Tissue Res, pp. 399: 393-399.

Hyaluronan catabolism: a new metabolic pathway. Stern et al. Eur J Cell Biol, 2004, pp. 83: 317-325.

Aggrecan, aging, and assembly in articular cartilage. Dudhia. 2005, Cell MolLife Sci, pp. 62: 2241-2256.

Collagen hydrolysate for the … and other joint …: a review of the literature. Bello et al. 2006, Curr Med Res Opin, pp. 22(11): 2221-2232.

Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation. Schauss et al. 2007, Food Chem Toxicol, pp. 45: 315-321.

Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases. Dai et al. 2007, Am J Path, pp. 282: 1451-1561.

Articular cartilage: structure, injuries and review of management. Bhosale et al. 2008, Brit Med Bull, pp. 87: 77-95.
Hyaluronan facilitates transforming …. Meran et al. 2008, J Biol Chem, pp. 283: 6530-6545.

Hyaluronan synthesis and degradation in cartilage and bone. Bastow. 2008, Cell Mol Life Sci, pp. 65: 395-413.

Native hyaluronic acid in dermatology—results of an expert meeting. Wiest et al. J Dtsch Dermatol Ges, 2008, pp. 6: 176-180.

Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Fisher et al. 2009, Am J Path, pp. 174: 101-114.

Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving … : a randomized, double-blind, placebo-controlled trial. Schauss et al. 2012, J Agric Food Chem, pp 60: 4096-4101.

Ingestion of BioCell Collagen(®), a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Schwartz et al. 2012, Clin Interv Aging, pp. 7: 267-273.

Evaluation of the effects of BioCell Collagen, a novel cartilage extract, on connective tissue support and functional recovery from exercise. Lopez et al. 2015, Integr Med (Encinitas), pp. 14: 30-38.

Novel hydrolyzed chicken sternal cartilage extract improves facial epidermis and connective tissue in healthy adult females: a randomized, double-blind, placebo-controlled trial. Schwartz et al. 2019, Altern Ther Health Med, pp. 25: 12-29.

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