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Hyaluronic Acid in Biocell Collagen II Found to Have Significant Absorption and Bioavailability in Clinical Study


NEWPORT BEACH, California, February 2, 2004- The results of a double blind clinical study demonstrating that the naturally occurring Hyaluronic Acid (HA) in the BioCell Collagen II® product has significant peak absorption and steady state bioavailability in normal volunteer subjects were released by BioCell Technology LLC, the exclusive suppliers of the Patented BioCell Collagen II® ingredient. Dr. William Judy, senior scientist at SIBR Research, referred to the study as “groundbreaking science,” emphasizing BioCell Technology’s breakthrough form of a lower molecular weight HA created utilizing proprietary technology, which is absorbed and thus quickly available for usage by the body. In contrast, prior published studies found that other HA forms were not absorbed and hence unavailable to the human body.

BioCell Collagen II® HA considerably rose in the blood in four hours and peaked at a level 7008.62% above control in twelve (12) hours (P0.05) in a 36-hour peak absorption trial utilizing a single dose. HA was rapidly degraded in the circulation to two metabolites 1/600th the size of the ingested HA.

After seven (7) days in a 28-day steady state bioavailability study using a constant daily dose, BioCell Collagen II® HA and its metabolites in the blood became stable, and these metabolites remained significantly increased (p0.001) throughout the study (HA at 3542.58% above control and HA metabolite at 11890.15% above control).

“This groundbreaking research on hyaluronic acid, a key component of the unique matrix of BioCell Collagen II®, which consists of Collagen Type II, Chondroitin Sulfate, and Hyaluronic Acid, demonstrates a synergistic effect that allows for the impressive absorption shown in these exciting and promising studies.” Suhail Ishaq, Vice President of BioCell Technology, LLC, stated, “BioCell Technology has expanded its intellectual property portfolio and has a patent pending to cover oral and topical uses of hyaluronic acid produced from various natural sources for use in nutritional supplements and cosmetics.”

This study employing the BioCell Collagen II® product clearly reveals that this HA form possesses the physical qualities required to allow it and its metabolites to flow rapidly from the circulation to the tissues by measuring the rate and magnitude of HA absorption and bioavailability. These findings back up BioCell Collagen IIpreviously ®’s demonstrated efficacy in the management of joint and skin care.


BioCell Technology, LLC, founded in 1997, pioneered the applications of Sternum Collagen Type II, the most concentrated natural source of type II collagen available. It is the sole provider of BioCell Collagen IITM. Under the terms of the United States Patent, BioCell Technology, LLC has the exclusive right to market BioCell Collagen II. BioCell Collagen IITM is a trademarked logo that can be displayed on its clients’ labels and sold under their own brand name or formulae.

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