Biocell Guide

Biocell Guide | Biocell Liquid Collagen


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Monday, July 30, 2012, Newport Beach, CA- BioCell Technology, LLC announces publication of the first human skin study of BioCell Collagen® in the Journal of Clinical Interventions in Aging ( This study enrolling 26 women between the ages of 35 to 59 demonstrated the safety and significant efficacy of orally ingested BioCell Collagen in improving the visible signs of aging and dermal aging parameters measured with bioinstrumentation. Together with an earlier publication of the outcome of a human clinical trial in 80 subjects with joint discomfort, this study has solidified BioCell Collagen as a highly-differentiated, holistic healthy aging dietary ingredient promoting both joint health and skin beauty from within. 

The global ‘beauty from within’ category, also known as nutricosmetics or cosmeceuticals, is currently estimated to be $2 billion and is rapidly expanding to projections as high as $4 billion by 2015.   This growth is fueled primarily by aging baby boomers and increased consumer awareness regarding incorporating nutricosmetics into the daily skincare regimen. “We see great business opportunities in these markets as formulators look for a strongly substantiated ingredient like BioCell Collagen. We continue to substantiate BioCell Collagen by the results of rigorous human clinical studies, such as we are announcing today” said Suhail Ishaq, president of BioCell Technology. 

As its name suggests, nutricosmetics lies at the intersection of nutritional supplements on the one hand, and skin care cosmetics on the other. It refers to the recent development of orally ingested nutritional supplements that promote healthier and more youthful looking skin. “The body uses nutrition to regenerate, replenish and support the complex interior structure of the skin—from inside the body,” says Joosang Park, PhD, vice president of scientific affairs at BioCell Technology.   He adds, “Since the surface of the skin acts as a barrier, most topical cosmetic applications can only deliver superficial results. However, the building blocks needed to support the largest organ in the body, the skin itself, can only be supplied from inside the body.”

Study details
This study investigated the effects of 1 g daily ingestion of BioCell Collagen on several parameters relevant to aged appearance of the facial skin. These parameters included dryness, wrinkles, lines, and collagen content. After 12 weeks, the subjects who were aged 35 to 59 years showed a significant reduction of skin dryness/scaling (76%) as well as reduction in fine lines and wrinkles (13.2%), as compared to baseline levels. The improved appearance was explained by internal metabolic shift in the dermis, leading to an increase in collagen content (3.5%) and in blood microcirculation (15%). In this study, BioCell Collagen was shown to elicit several key physiological events which counteract both natural and photo-aging processes to improve visible aging signs in the face. As a result, a majority of the study participants experienced a remarkable improvement in skin texture, together with hydration, reduced scaling, and improved blood microcirculation. 

A holistic approach to skin, joint, and connective tissue health 
BioCell Collagen is differentiated from other healthy aging and collagen ingredients by its unique molecular nature and associated biochemical properties which are closely associated with clinical efficacy. This patented ingredient is a naturally-occurring matrix of hydrolyzed collagen and low molecular weight glycosaminoglycans (GAGs) such as hyaluronic acid (HA) and chondroitin sulfate, all of which are crucial for the health of various connective tissues including joint, skin dermis, tendons, ligaments, and blood vessels. Studies indicate that BioCell Collagen is highly bioavailable and biologically active with the ability to stimulate cartilage and skin producing cells.  The increase in dermal collagen, primarily type I, implies that BioCell Collagen has a potential in the health of other connective tissues such as ligaments and tendons where collagen type I and GAGs are key structural molecules. BioCell Collagen holds great promise as a key ingredient applicable to a wide spectrum of consumers, from the young adult to the middle aged on through the senior population. The focus of an older population is on optimal aging and mitigating degenerative processes, while younger consumers are interested in preventing sport-related injuries to maintain an active lifestyle.     

About BioCell Collagen®:
BioCell Collagen® is an innovative dietary ingredient marketed as a healthy aging nutritional supplement that promotes both healthy joints and more youthful-looking skin.  It is unique in that it is a naturally-occurring matrix whose three major constituents, collagen type II, chondroitin sulfate, and hyaluronic acid, are reduced to highly-bioavailable, very low molecular weight forms due to its patented hydrolysis process.  

About BioCell Technology:
Founded in 1997, BioCell Technology, LLC is the exclusive supplier of BioCell Collagen II® and owns the exclusive rights to market it under US Patents. The product logo is registered and is available for display on the labels of BioCell Technology, LLC’s private label clients for marketing under their own brand names or formulas.  For more information on BioCell Collagen II, please contact BioCell Technology, LLC at (714) 632-1231 or visit

Biocell Guide